Quick summary

Type of medicine

Traitement topique contre l’acné

Works by

Reducing the number of bacteria on the surface of the skin, unclogging pores, and limiting the formation of comedones. It helps dry out existing blemishes and prevent new ones from forming.

Active ingredient

Adapalene

Effective within

Visible improvement typically occurs after 4 to 8 weeks of consistent use.

Generic?

No

Side effects

Dry skin, irritation of the skin, burning sensation of the skin, redness of the skin (erythema)

Medication details

Description

Differin Gel (Adapalene) is a highly effective topical treatment specifically designed to combat acne at its source. Belonging to a group of medicines called retinoids (derived from Vitamin A), it is particularly potent against comedonal acne (blackheads and whiteheads) and mild to moderate inflammation.

Unlike antibiotics that kill bacteria, Differin works by regulating the turnover of skin cells. It normalizes the shedding of skin cells inside the hair follicles, preventing dead skin and oil from clogging pores. This deep exfoliating action not only treats existing blemishes but also helps stop new acne lesions from forming.

Ingredients

The active substance is adapalene. Differin contains 0.1% w/w of adapalene and the other ingredients are carbomer 940, propylene glycol (E1520), poloxamer 182, disodium edetate, methylparahydroxybenzoate (E218), phenoxyethanol, sodium hydroxide and purified water.

Side effects

Irritation cutanée, rougeur, dessèchement, démangeaisons, pellicules, sensation de brûlure légère

Warnings

Le Benzoyl Peroxyde peut provoquer une irritation, une rougeur ou une sécheresse cutanée, surtout au début du traitement. Évitez de l’utiliser sur une peau irritée, coupée ou brûlée par le soleil. Ce produit peut également blanchir les tissus et les cheveux — manipulez-le avec soin.
N’utilisez pas d’autres traitements anti-acné agressifs simultanément sans avis médical, car cela peut accentuer l’irritation.
Consultez un professionnel de santé si les symptômes s’aggravent ou persistent après plusieurs semaines d’utilisation.

Frequently Asked Questions

Is it normal for my skin to feel irritated at first?

Yes, this is very common during the first few weeks. You may experience some redness, dryness, or a burning sensation as your skin adjusts to the retinoid. To reduce this, you can apply the gel every other night initially or use a moisturizer 30 minutes after application.

Why does my acne seem worse after starting?

This is often called "purging." Because Adapalene accelerates cell renewal, deep-seated impurities are brought to the surface faster, which may look like a breakout. This is a sign the medication is working and usually clears up within a few weeks.

Can I use this if I am pregnant?

No. The use of retinoids like Adapalene is strictly contraindicated during pregnancy to ensure the safety of the unborn child. If you are planning a pregnancy, stop using this medication.

Does this make my skin sensitive to the sun?

Yes, Adapalene makes your skin more sensitive to UV light. It is important to avoid excessive sun exposure and sunbeds, and to always wear a broad-spectrum sunscreen (SPF 30+) during the day, even if it is cloudy.

Can I combine this with other acne products?

Be cautious with other drying products like alcohol-based toners or harsh scrubs, as this can cause severe irritation. If you want to use other active ingredients (like benzoyl peroxide), it is often advised to use them in the morning and apply Differin in the evening.

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